Published by or in Collaboration with Probetex, Inc
Patel M, Velagapudi C, Burns HS, Doss R, Lee, MJ, Mariappan M, Wagner B, Arar M, Barnes VL, Abboud HE, Barnes JL. Mouse metanephric mesenchymal cell-derived angioblasts undergo vasculogenesis in three-dimensional culture. Am J Pathol 188: 768-784, 2018. Probetex, Inc, Univ TX Hlth Sci Ctr, San Antonio, TX. (CMMM-1 and CMUB-1: Mouse Kidney Primordial Cells).
Sun H, Olsen HS, Merigeon EY, So E, Burch E, Kinsey S, Papadimitriou JC, Drachenberg CB, Bentzen SM, Block DS, Strome SE, Zhang X: Recombinant human IgG1 based Fc multimers, with limited FcR bindng capacity, can effectively inhibit complement-mediated disease. J Autoimmun 84: 87-98, 2017. (rats) University of Maryland School of Medicine, Gliknik, Inc., Chengdu Military General Hospital China. Antisera, Pre-Clinical Testing, Histopathology, Image Analysis
Riser BL, Najmabadi F, Garchow K, Barnes JL, Peterson DR, Sukowski EJ: Treatment with matricellular protein CCN3 blocks and/or reverses fibrosis development in obesity with diabetic nephropathy. Am J Pathol 184:2908–2921, 2014. Rosalind Franklin University of Medicine and Science, Baxter Healthcare, Probetex, Inc. (Histopathology, Image Analysis).
Velagapudi C, Nilsson R-P, Barnes VL, Arar M, Abboud HE, Barnes JL. Reciprocal induction of simple organogenesis by mouse kidney progenitor cells in three-dimensional co-culture. Am J Pathol 180:819-830, 2012. Link (Cover Photo, February Issue). Probetex, Inc, Univ TX Hlth Sci Ctr, San Antonio, TX. (CMMM-1 and CMUB-1: Mouse Kidney Primordial Cells).
McIntosh LM, Barnes JL, Barnes VL, McDonald JR. Selective CCR2-targeted macrophage depletion ameliorates experimental mesangioproliferative glomerulonephritis. Clin Exp Immunol 155:295-303, 2009. Osprey Pharma, Probetex, Inc. (Contract Research, Pre-Clinical Testing, Histopathology)
Published by Customers Using Probetex Products
PTX-001: Sheep Anti-Glomerular Basement Membrane (GBM) Serum:
Chen YC, Waghorn PA, Rosales IA, Arora G, Erstad DJ, Rotile NJ, Jones CM, Ferreira DS, Wei L, Martinez RVP, Schlerman FJ, Wellen J, Fuchs BC, Colvin RB, Ay I, Caravan P. Molecular MR imaging of renal fibrogenesis in mice. J Am Soc Nephrol34(7):1159-1165, 2023. doi: 10.1681/ASN.0000000000000148. Epub 2023 Apr 24. PMID: 37094382. Mass General Hospital, Harvard University. (Mice).
Douté M, Sannier A, Even G, Tran TT, Gaston AT, Delbosc S, Loyau S, Bruneval P, Witko-Sarsat V, Mouthon L, Nicoletti A, Caligiuri G, Clement M. Thrombopoietin-dependent myelo-megakaryopoiesis fuels thromboinflammation and worsens antibody-mediated chronic renal microvascular injury. J Am Soc Nephrol. 2023 Apr 5. doi: 10.1681/ASN.0000000000000127. Epub ahead of print. PMID: 37022108. INSERM (Mice)
Editorial: Hickey, MJ: Kidney-derived thrombopoietin and platelet generation--A proinflammatory loop in CKD. J Am Soc Nephrol 34:1128-1131, 2023.
Liu WB, Huang GR, Liu BL, Hu HK, Geng J, Rui HL, Gao C, Huang YJ, Huo GY, Mao JR, Lu CJ, Xu AL. Single cell landscape of parietal epithelial cells in healthy and diseased states. Kidney Int. 2023 Apr 24:S0085-2538(23)00267-3. doi: 10.1016/j.kint.2023.03.036. Epub ahead of print. PMID: 37100348. Mice, PTX001-AGBM)
Charrin, E., Dabaghie, D., Sen, I. et al. Soluble Klotho protects against glomerular injury through regulation of ER stress response. Commun Biol 6, 208 (2023). https://doi.org/10.1038/s42003-023-04563-1 Karolinska Institutet, University of Cologne, Royal Institute of Technology, Uppsala University, University of Groningen, Universität Oldenburg. (Mice)
Shioda R, Jo-Watanabe A, Okuno T, Saeki K, Nakayama M, Suzuki Y, Yokomizo T. The leukotriene B4 /BLT1-dependent neutrophil accumulation exacerbates immune complex-mediated glomerulonephritis. FASEB J. 2023 Feb;37(2):e22789. doi: 10.1096/fj.202201936R. PMID: 36692419.
Chen YC, Waghorn PA, Rosales IA, Arora G, Erstad DJ, Rotile NJ, Jones CM, Ferreira DS, Wei L, Martinez RVP, Schlerman FJ, Wellen J, Fuchs BC, Colvin RB, Ay I, Caravan P. Molecular MR Imaging of Renal Fibrogenesis in Mice. J Am Soc Nephrol. 2023 Apr 24. doi: 10.1681/ASN.0000000000000148. Epub ahead of print. PMID: 37094382.
Alli AA, Desai D, Elshika A, Conrad M, Proneth B, Clapp W, Atkinson C, Segal M, Searcy LA, Denslow ND, Bolisetty S, Mehrad B, Morel L, Scindia Y. Kidney tubular epithelial cell ferroptosis links glomerular injury to tubulointerstitial pathology in lupus nephritis. Clin Immunol. Volume 248, March 2023, in press. Epub ahead of print. PMID: 36566913. (Mice)
Fayçal CA, Oszwald A, Feilen T, Cosenza-Contreras M, Schilling O, Loustau T, Steinbach F, Schachner H, Langer B, Heeringa P, Rees AJ, Orend G, Kain R. An adapted passive model of anti-MPO dependent crescentic glomerulonephritis reveals matrix dysregulation and is amenable to modulation by CXCR4 inhibition. Matrix Biol. 106:12-33, 2022. Epub 2022 Jan 13. PMID: 35032611. (Mice)
Kim K, Na M, Oh K, Cho E, Han SS, Chang S. Optimized single-step optical clearing solution for 3D volume imaging of biological structures. Commun Biol. 5:431-441, 2022. PMID: 35534680; PMCID: PMC9085829. (Mice)
Kim MG, Yun D, Kang CL, Hong M, Hwang J, Moon KC, Jeong CW, Kwak C, Kim DK, Oh KH, Joo KW, Kim YS, Lee DS, Han SS. Kidney VISTA prevents IFN-γ/IL-9 axis-mediated tubulointerstitial fibrosis after acute glomerular injury. J Clin Invest. 2022 Jan 4;132(1):e151189. doi: 10.1172/JCI151189. PMID: 34752423; PMCID: PMC8718152.
Martin CE, Phippen NJ, Keyvani Chahi A, Tilak M, Banerjee SL, Lu P, New LA, Williamson CR, Platt MJ, Simpson JA, Krendel M, Bisson N, Gingras AC, Jones N. Complementary Nck1/2 Signaling in Podocytes Controls α Actinin-4-Mediated Actin Organization, Adhesion, and Basement Membrane Composition. J Am Soc Nephrol. 2022 Aug;33(8):1546-1567. doi: 10.1681/ASN.2021101343. PMID: 35906089; PMCID: PMC9342632.
Butt L, Unnersjö-Jess D, Höhne M, Hahnfeldt R, Reilly D, Rinschen MM, Plagmann I, Diefenhardt P, Brähler S, Brinkkötter PT, Brismar H, Blom H, Schermer B, Benzing T. Super-resolution imaging of the filtration barrier suggests a role for podocin r229q in genetic predisposition to glomerular disease. J Am Soc Nephrol. 33:138-154, 2022. PMID: 34853150. (Mice)
Melica ME, Antonelli G, Semeraro R, Angelotti ML, Lugli G, Landini S, Ravaglia F, Regina G, Conte C, De Chiara L, Peired AJ, Mazzinghi B, Donati M, Molli A, Steiger S, Magi A, Bartalucci N, Raglianti V, Guzzi F, Maggi L, Annunziato F, Burger A, Lazzeri E, Anders HJ, Lasagni L, Romagnani P. Differentiation of crescent-forming kidney progenitor cells into podocytes attenuates severe glomerulonephritis in mice. Sci Transl Med. 14657: 2022. PMID: 35947676; PMCID: PMC7614034. (Mice).
Rousselle A, Sonnemann J, Amann K, Mildner A, Lodka D, Kling L, Bieringer M, Schneider U, Leutz A, Enghard P, Kettritz R, Schreiber A. CSF2-dependent monocyte education in the pathogenesis of ANCA-induced glomerulonephritis. Ann Rheum Dis. 81:1162-1172, 2022. PMID: 35418479; PMCID: PMC9279749. (Mice)
Bjørnholm KD, Ougaard ME, Skovsted GF, Knudsen LB, Pyke C. Activation of the renal GLP-1R leads to expression of Ren1 in the renal vascular tree. Endocrinol Diabetes Metab. 19;4:e00234, 2021. PMID: 34277961; PMCID: PMC8279630. (Mice)
Pagan JD, Vlamakis H, Gaca A, Xavier RJ, Anthony RM. Modulating T follicular cells in vivo enhances antigen-specific humoral immunity. J Immunol. 206:2583-2595, 2021. PMID: 34011521; PMCID: PMC8164984. (Mice)
Ren J, Xu Y, Lu X, Wang L, Ide S, Hall G, Souma T, Privratsky JR, Spurney RF, Crowley SD. Twist1 in podocytes ameliorates podocyte injury and proteinuria by limiting CCL2-dependent macrophage infiltration. JCI Insight. 6:e148109, 2021. PMID: 34369383; PMCID: PMC8410065. (Mice)
Ren J, Lu X, Hall G, Privratsky JR, Robson MJ, Blakely RD, Crowley SD. IL-1 receptor signaling in podocytes limits susceptibility to glomerular damage. Am J Physiol Renal Physiol. 2022 Feb 1;322(2):F164-F174. doi: 10.1152/ajprenal.00353.2021. Epub 2021 Dec 13. PMID: 34894725; PMCID: PMC8782651.
Möller-Hackbarth K, Dabaghie D, Charrin E, Zambrano S, Genové G, Li X, Wernerson A, Lal M, Patrakka J. Retinoic acid receptor responder1 promotes development of glomerular diseases via the Nuclear Factor-κB signaling pathway. Kidney Int. 100:809-823, 2021. PMID: 34147551. (Mice).
Commentary to Moller: Chen A, Lee K, He JC. Autocrine and paracrine effects of a novel podocyte gene, RARRES1. Kidney Int. 100:745-747, 2021. PMID: 34556297.
Chung, J-J; Goldstein, L; Chen, Y-JJ; Lee, J; Webster, JD, Roose-Girma, M. Paudyal, SC, Modrusan, Z, Dey, A, Shaw, AS. Single-Cell Transcriptome Profiling of the Kidney Glomerulus Identifies Key Cell Types and Reactions to Injury. JASN 31(10):p 2341-2354, October 2020. | DOI: 10.1681/ASN.2020020220
Jing C, Castro-Dopico T, Richoz N, et al. Macrophage metabolic reprogramming presents a therapeutic target in lupus nephritis. PNAS 117 (26):15160-15171, 2020. (Mice). University of Cambridge, National Institute of Arthritis and Musculoskeletal and Skin Disease.
Dylewski J, Tonsawan P, Garcia G, Lewis L, Blaine J. Podocyte-specific knockout of the neonatal Fc receptor (FcRn) results in differential protection depending on the model of immune-mediated kidney disease. bioRxiv 2020.03.02.972851 (Mice). University of Colorado Denver, Anschutz Medical Campus
Liu F, Dai S, Feng D, et al. Distinct fate, dynamics and niches of renal macrophages of bone marrow or embryonic origins. Nat Commun. 2020;11(1):2280. Published 2020 May 8. doi:10.1038/s41467-020-16158-z. (Mice). Tulane University School of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Temple University Lewis Katz School of Medicine.
Rodriguez PQ, Unnersjö-Jess D, Zambrano SS, Guo J, Möller-Hackbarth K, Blom H, Jahnukainen T, Ebarasi L, Patrakka J. Inactivation of mediator complex protein 22 in podocytes results in intracellular vacuole formation, podocyte loss and premature death. Sci Rep. 2020 Nov 18;10(1):20037. doi: 10.1038/s41598-020-76870-0. PMID: 33208756; PMCID: PMC7676236.
Solanki AK, Srivastava P, Rahman B, Lipschutz JH, Nihalani D, Arif E. The use of high-throughput transcriptomics to identify pathways with therapeutic significance in podocytes. Int. J. Mol. Sci. 21: 274, 2020. (Mice). Medical University of South Carolina
Wen Y, Rudemiller NP, Zhang J, et al. TNF-α in T lymphocytes attenuates renal injury and fibrosis during nephrotoxic nephritis. Am J Physiol Renal Physiol.;318(1):F107-F116, 2020. (Mice). Durham Veterans Affairs and Duke University Medical Center, Durham, North Carolina.
Kim EY, Shotorbani PY, Dryer SE. TRPC6 inactivation does not affect loss of renal function in nephrotoxic serum glomerulonephritis in rats, but reduces severity of glomerular lesions. Biochem Biophys Rep. 17:139-150, 2019. (Rats) University of Houston and Baylor University, Houston, TX. Link
Gualdani R, Seghers F, Yerna X, Schakman O, Tajeddine N, Achouri Y, Tissir F, Devuyst O, Gailly P Mechanical activation of TRPV4 channels controls albumin reabsorption by proximal tubule cells. Sci Signal. 2020 Oct 13;13(653):eabc6967. doi: 10.1126/scisignal.abc6967. PMID: 33051259.
.(Mice). Université catholique de Louvain, University of Zurich
Arif E, et al. The motor protein Myo1c regulates transforming growth factor-β-signaling and fibrosis in podocytes. Kidney Intl, 96(1):139-158, 2019. (Mice). Medical University of South Carolina, Charleston, University of Pennsylvania, TU Dresden, College of Charleston, Augusta University, GA. Research Gate Post
Müller MB, Hoppe JM, Bideak A, Lux M, Lindenmeyer MT, Müller S, Eltrich N, Ryffel B, et al. Exclusive expression of transmembrane TNF aggravates acute glomerulonephritis despite reduced leukocyte infiltration and inflammation. Kidney Int, 95: 75–93, 2019. (Mice) Universität München, Ludwig-Maximilians-Universität München, Munich, Germany
Arif E, Solanki AK, Srivastava P, Rahman B, Fitzgibbon WR, Deng P, Budisavljevic MN, Baicu CF, Zile MR, Megyesi J, Janech MG, Kwon SH, Collier J, Schnellmann RG, Nihalani D. Mitochondrial biogenesis induced by the β2-adrenergic receptor agonist formoterol accelerates podocyte recovery from glomerular injury. Kidney Int. S0085-2538(19)30458-2. doi: 10.1016/j.kint.2019.03.023. [Epub ahead of print]2019 pii: (Mice). Medical University of South Carolina, Ralph H. Johnson VA Medical Center, John C McClelland VA Hospital, College of Charleston, Augusta University, University of Arizona, Southern Arizona VA Health Care System.
Wen Y, Lu X, Ren J, Privratsky JR, Yang B, Rudemiller NP, Zhang J, Griffiths R, Jain MK, Nedospasov SA, Liu BC, Crowley SD. KLF4 in macrophages attenuates TNFα-mediated kidney injury and fibrosis. J Am Soc Nephrol. 30:1925-1938, 2019. (Mice). Duke University Medical Center, Duke-National University of Singapore, Durham Veterans Affairs Medical Center
Unnersjo-Jess D, Scott L, Sevilla SZ, Patrakka J, Blom H, Brismar H. Confocal super-resolution imaging of the glomerular filtration barrier enabled by tissue expansion. Kidney Int. 93:1008-1013, 2018. (Mice). Royal Institute of Technology, Karolinska Institutet, Stockholm, Sweden.
Ougaard MKE, Kvist PH, Jensen HE, Hess C, Rune I, Sondergaard H. Murine nephrotoxic nephritis as a model of chronic kidney disease. Int J Nephrol Article ID 8424502 pg 1-12, 2018. (Mice) Novo Nordisk, Univ Copenhagen, Denmark.
Pagan JD, Kitaoka M, Anthony RM. Engineered sialylation of pathogenic antibodies in vivo attenuates autoimmune disease. Cell. 172(3):564-577, 2018. (Mice) Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Featured in "Research Highlights" McHugh J. Autoimmunity: Glycoengineering has therapeutic potential. Nat Rev Rheumatol. 14(3):121, 2018. Commentary
Zambrano S, Rodriguez PQ, Guo J, Möller-Hackbarth K, Schwarz A, Patrakka J. FYVE domain-containing protein ZFYVE28 regulates EGFR-signaling in podocytes but is not critical for the function of filtration barrier in mice. Sci Rep. 16;8(1):4712-. 2018. (Mice). Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden.
Bideak A, Blaut A, Hoppe JM, Müller MB, Federico G, Eltrich N, Gröne HJ, Locati M, Vielhauer V. The atypical chemokine receptor 2 limits renal inflammation and fibrosis in murine progressive immune complex glomerulonephritis. Kidney Int. 93(4):826-841, 2018. (Mice). Ludwig-Maximilians-University Munich, Munich, Germany, German Cancer Research Center, Heidelberg, Germany, Humanitas Clinical and Research Center, Rozzano, Italy, Università degli Studi di Milano, Milan, Italy.
See Commentary:
Eller K, Rosenkranz AR. Atypical chemokine receptors—“chemokine PACMANs” as new therapeutic targets in glomerulonephritis Kidney Int. 93 (4): 774-775, 2018. Abstract
Ougaard ME, Jensen HE, Thuen ID, Petersen EG, Kvist PH. Inhibitors of the renin-angiotensin system ameliorates clinical and pathological aspects of experimentally induced nephrotoxic serum nephritis. Ren Fail. 40:640-648, 2018. (Mice) Novo Nordisk and University of Copenhagen , Frederiksberg , Denmark.
Ougaard ME, Sembach FE, Kvist PH, Tonnesen M, Frederiksen KS, Egfjord M, Jensen HE, Galsgaard ED. Temporal regulation of glomerular and cortical tubulointerstitial genes involved in the development of nephrotoxic serum nephritis. Nephron. 140(3):218-230, 2018. (Mice). Novo Nordisk A/S and University of Copenhagen, Copenhagen, Denmark.
Hachmo Y, Kalechman Y, Skornick I, Gafter U, Caspi RR, and Sredni B: The small tellurium compound AS101 ameliorates rat crescentic glomerulonephritis: association with inhibition of macrophage caspase-1 activity via very late antigen-4 inactivation. Front Immunol. 8: 240-, 2017. doi: 10.3389/immu.2017.00240 PMCID: PMC5339302. (Rats) C.A.I.R. Institute, The Safdiè AIDS and Immunology Research Center; Laboratory of Immunology, National Eye Institute, National
Institutes of Health, Bethesda, MD, USA. Link
Hsu M-F, Betaieb A, Ito Y, Graham J, Havel PJ, Haj FG. Protein tyrosine phosphatase Shp2 deficiency in podocytes attenuates lipopolysaccharide-induced proteinuria. Scientific Reports 7: 461 2017. (Mice). UC-Davis Univ Tennessee-Knoxville Tennessee, USA. Link
Velez JCQ, Arif E, Rodgers J, Hicks MP, Arthur JM, Nihalani D, Bruner ET, Budisavljevic MN, Atkinson C, Fitzgibbon WR, Janech MG. Deficiency of the angiotensinase aminopeptidase A increases susceptibility to glomerular injury. J Am Soc Nephrol: 28(7):2119-2132, 2017. (Mice). Ochsner Clinic Foundation, New Orleans, LA, Medical University of South Carolina, Charleston, SC, Augusta University, Augusta, GA, University of Arkansas for Medical Sciences, Little
Rock, AR. Link
Bettaieb A, Koike S, Chahed S, Zhao Y, Bachaalany S, Hashoush N, Graham J, Fatima H, Havel PJ, Gruzdev A, Zeldin DC, Hammock BD, Haj FG. Podocyte-specific soluble epoxide hydrolase deficiency in mice attenuates acute kidney injury. FEBS J. 284(13):1970-1986, 2017.(Mice). UC Davis, Univ of Tenn-Knoxville, NIEHS PMCID:
Bosma M, Gerling M, Pasto J, Georgiadi A, Graham E, Shilkova O, Iwata Y, Almer S, Soderman J, Toftgard R, Wermeling F, Bostrom EA, Bostrom PA. FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice. Nature Commun 7: 11314. Apr 12 2016. (Mice) Karolinska Institute, Stockholm Sweden. Link
Mulay SR, Romoli S, Desai J, Honarpischeh, MM, Kumar SV, Anders H-J. Murine double minute-2 inhibition ameliorates established crescentic glomerulonephritis. Am J Pathol. 186: 1442-153, 2016. (Mice) Medizinische Klinik und Poliklinik University Hoispital of Ludwig-Maximillians-University , Munich, Germany. Link
Zheng W, Warner R, Ruggeri R, Su C, Cortes C, Skoura A, Ward J, Ahn K, Kalgutkar A, Sun D, Maurer TS, Bonin PD, Okerberg C, Bobrowski W, Kawabe T, Zhang Y, Coskran T, Bell S, Kapoor B, Johnson K, Buckbinder L. PF-1355, a mechanism-based myeloperoxidase inhibitor, prevents immune complex vasculitis and anti–glomerular basement membrane glomerulonephritis. J Pharmacol Exp Ther 353:288–298, 2015. (Mice). Pfizer and University of Michigan. Link
Pavkovic M, Riefke B, Frisk AL, Gröticke I, Ellinger-Ziegelbauer H. Glomerulonephritis-induced changes in urinary and kidney MicroRNA profiles in rats. Toxicol Sci. 145(2), 348–359, 2015. (Rats). Bayer Pharma AG and Harvard Medical School.
Kumar SV, Kulkarni OP, Mulay SR, Darisipudi MN, Romoli S, Thomasova D, Scherbaum CR, Hohenstein B, Hugo C, Müller S, Liapis H, Anders HJ. Neutrophil Extracellular Trap-Related Extracellular Histones Cause Vascular Necrosis in Severe GN. J Am Soc Nephrol. 26 (10):2399-2413, 2015 (Mice) (Ludwig-Maximilians-University of Munich, Munich). Link
Kim J, Imig JD, Yang J, Hammock BD, Padanilam BJ: Inhibition of soluble epoxide hydrolase prevents renal interstitial fibrosis and inflammation. Am J Physiol Renal Physiol 307: F971-F980, 2014. (Mice). (University of Nebraska USA).
Schwarz M, Taubitz A, Eltrich N, Mulay SR, Allam R, Vielhauer V: Analysis of TNF-mediated recruitment and activation of glomerular dendritic cells in mouse kidneys by compartment-specific flow cytometry. Kidney Int 84: 116-129, 2013. (Mice) (Ludwig-Maximillians-Univeristy of Munich).
Lichtnekert J, Kulkarni OP, Mulay SR, Rupanagudi KV, Ryu M, Allam R, Vielhauer V, Muruve D, Lindenmeyer MT, Cohen CD, Anders H-J. Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1. PLoS ONE 6(10): e26778. doi:10.1371/journal.pone.0026778. October 2011. (Mice) (Ludwig-Maximillians-Univeristy of Munich).
Rufanova VA, Lianos E, Alexanian A, Sorokina E, Sharma M, McGinty A, Sorokin A: G3G overexpression in glomerular epithelial cells during anti-GBM-induced glomerulonephritis. Kidney Int 75:31-40, 2009. (Mice) (Medical College of Wisconsin).
PTX-002: Sheep Anti-Fx1A Serum (Heymann Nephritis):
Chen B, Guan X, Gunning WT, Ge Y, Gohara AF, Dworkin LD, Gong R. Negative modulation of B cell activation by melanocortin 1 receptor signaling protects against membranous nephropathy. J Am Soc Nephrol. 34:467-481, 2023. doi: 10.1681/ASN.2022050605. Epub 2022 Nov 29. PMID: 36446431. (Rats)
Gao S, Cui Z, Zhao MH. Complement C3a and C3a receptor activation mediates podocyte injuries in the mechanism of primary membranous nephropathy. J Am Soc Nephrol. Sep;33(9):1742-1756, 2022. Epub 2022 Jul 1. PMID: 35777783; PMCID: PMC9529185. (Rats) Editorial: Kettritz R, Schreiber A. Complement is complimentary in membranous nephropathy. J Am Soc Nephrol. 33:1631-1633, 2022. PMID: 35831021; PMCID: PMC9529176.
Coyne MJ, Schultze AE, McCrann DJ 3rd, Murphy RE, Cross J, Strong-Townsend M, Drake C, Mack R. Evaluation of renal injury and function biomarkers, including symmetric dimethylarginine (SDMA), in the rat passive Heymann nephritis (PHN) model. PLoS One. 17:e0269085, 2022. PMID: 35622875; PMCID: PMC9140233.
Gao Y, Dai H, Zhang N, Jiang H, Zhang Z, Feng Z, Dong Z, Liu W, Liu F, Dong X, Zhao Q, Zhou X, Du J, Zhang N, Rui H, Liu B. The ameliorative effect of Mahuang fuzi and Shenzhuo decoction on membranous nephropathy of rodent model is associated with autophagy and Wnt/β-catenin pathway. Front Pharmacol. 13:820130, 2022. PMID: 35529432; PMCID: PMC9068930. (Rats)
Wang X, Liu J, Tian R, Zheng B, Li C, Huang L, Lu Z, Zhang J, Mao W, Liu B, Bao K, Xu P. Sanqi oral solution mitigates proteinuria in rat passive Heymann nephritis and blocks podocyte apoptosis via Nrf2/HO-1 Pathway. Front Pharmacol. 12:727874, 2021. PMID: 34867334; PMCID: PMC8640486. (Rats) Erratum in: Front Pharmacol. 13:905693, 2022. PMID: 34867334; PMCID: PMC8640486.
Zhou HS, Cui Z, Wang H, Gao TT, Wang L, Wu J, Xiong ZY, Hao J, Zhao MH. The therapeutic effects of human embryonic stem cells-derived immunity-and-matrix regulatory cells on membranous nephropathy. Stem Cell Res Ther. 13:240, 2022. PMID: 35672767; PMCID: PMC9172125. (Rats)
Wang XH, Yang YN, Liang Y, Lang R, Zeng Q, Yan L, Yu RH, Wu CM. Structural modulation of gut microbiota during alleviation of experimental passive Heymann nephritis in rats by a traditional Chinese herbal formula. Biomed Pharmacother: 145:112475, 2022. (Rats)
Wang XH, Lang R, Zeng Q, Liang Y, Chen N, Ma ZZ, Yu RH. Jianpi Qushi Heluo formula alleviates renal damages in passive Heymann nephritis in rats by upregulating Parkin-mediated mitochondrial autophagy. Sci Rep. 11:18338, 2021. PMID: 34526554; PMCID: PMC8443625. (Rats)
Yin J, Lin J, Yu J, Wei X, Zhu B, Zhu C. Tetrandrine may treat membranous glomerulopathy via P13K/Akt signaling pathway regulation: therapeutic mechanism validation using Heymann nephritis rat model. Bioengineered. 12:6499-6515, 2021. PMID: 34463195 (Rats)
Fan K, Zeng L, Guo J, Xie S, Yu Y, Chen J, Cao J, Xiang Q, Zhang S, Luo Y, Deng Q, Zhou Q, Zhao Y, Hao L, Wang Z, Zhong L. Visualized podocyte-targeting and focused ultrasound responsive glucocorticoid nano-delivery system against immune-associated nephropathy without glucocorticoid side effect. Theranostics. 11:2670-2690, 2021. PMID: 33456566; PMCID: PMC7806481. (Rats)
Hu S, Han R, Chen L, Qin W, Xu X, Shi J, Zhu X, Zhang M, Zeng C, Tang Z, Bao H, Liu Z. Upregulated LRRC55 promotes BK channel activation and aggravates cell injury in podocytes. J Exp Med. 218:e20192373, 2021. PMID: 33346797; PMCID: PMC7756252. (Rats).
Pisarek-Horowitz A, Fan X, Kumar S, Rasouly HM, Sharma R, Chen H, Coser K, Bluette CT, Hirenallur-Shanthappa D, Anderson SR, Yang H, Beck LH Jr, Bonegio RG, Henderson JM, Berasi SP, Salant DJ, Lu W. Loss of Roundabout Guidance Receptor 2 (Robo2) in podocytes protects adult mice from glomerular injury by maintaining podocyte foot process structure. Am J Pathol. 2020 Mar 20. pii: S0002-9440(20)30024-9. [Epub ahead of print]. (PHN: Rats) https://ajp.amjpathol.org/article/S0002-9440(20)30024-9/pdf Boston University School of Medicine, Boston Medical Center, Pfizer, Inc.
Sun H, Olsen HS, Merigeon EY, So E, Burch E, Kinsey S, Papadimitriou JC, Drachenberg CB, Bentzen SM, Block DS, Strome SE, Zhang X: Recombinant human IgG1 based Fc multimers, with limited FcR bindng capacity, can effectively inhibit complement-mediated disease. J Autoimmun 84: 87-98, 2017. (rats) University of Maryland School of Medicine, Gliknik, Inc., Chengdu Military General Hospital China. Link
Nassiirpour R, Homer BL, Mathur S, Li Y, Li Z, Brown T, Carraher D, Warneke J, Bailey S, Percival K, O'Neil SP, Whiteley LO. Identification of promising urinary microRNA biomarkers in two rat models of glomerular injury. Toxicol Sci. 148 (1): 35-47, 2015 (rats) Pfizer Research and Development, Groton, CT. Link
Lindskog Jonsson A, Granqvist A, Elvin J, Johansson ME, Haraldsson B, Nystrom: Effects of melanocortin 1 receptor agonists in experimental nephropathies. Plos one 9 e87816, 2014. (rats) (University of Gothenburg, Sweden). Link
Lindskog A, Ebefors K, Johansson ME, Stefansson B, Granqvist A, Arnadottir M, Berg A-L, Nystrom J, Haraldsson B. Melanocortin 1 receptor agonists reduce proteinuria. J Am Soc Nephrol 21: 1290-1298, 2010. (rats). (University of Gothenburg, Sweden). Link
PTX-003: Anti-Thymocyte (Thy1) Serum:
Rufanova VA, Alexanian A, Ostendorf T, Bokenmeyer D, Prosser S, Miller B, Sorokin A: Endothelin signaling via guanine exchange factor C3G in renal glomerular mesangial cells. Can J Physiol Pharmacol 88:808-816, 2010. (Rats) (Medical College of Wisconsin, USA). Link
McIntosh LM, Barnes JL, Barnes VL, McDonald JR. Selective CCR2-targeted macrophage depletion ameliorates experimental mesangioproliferative glomerulonephritis. Clin Exp Immunol 155:295-303, 2009. (rats) (Ospery Pharmaceuticals, Canada). Link
Gullulu M, Akdag I, Kahvecioglu S, Filiz G and Savci V: Aldosterone blockage in proliferative glomerulonephritis prevents not only fibrosis, but proliferation as well. Renal Failure 28:509-514 2006. (rats) Uludag University Medical School, Bursa, Turkey. Link
CRGEp-1: Adult Rat Glomerular Epithelial Cells:
Müller T, Kalea AZ, Marquez A, Hsieh I, Haque S, Ye M, Wysocki J, Bader M, Batlle D. Apelinergic system in the kidney: implications for diabetic kidney disease. Physiol Rep. 2018 Dec; 6(23):e13939. doi: 10.14814/phy2.13939. (Mice). Northwestern University, Charité-Universitätsmedizin Berlin. University College London, Max Delbrück Center for Molecular Medicine, Berlin, German Center for Cardiovascular Research (DZHK), partner site Berlin, Berlin Institute of Health (BIH), University of Lübeck, Lübeck, Germany. Link
CMMM-1 or CMUB-1: Mouse Kidney Primordial Cells:
Gao G, Li X, Jiang Z, Osorio L, Tang YL, Yu X, Jin G, Zhou Z. Isthmin-1 (Ism1) modulates renal branching morphogenesis and mesenchyme condensation during early kidney development. Nat Commun. 2023 Apr 25;14(1):2378. doi: 10.1038/s41467-023-37992-x. PMID: 37185772; PMCID: PMC10130008.
Patel M, Velagapudi C, Burns HS, Doss R, Lee, MJ, Mariappan M, Wagner B, Arar M, Barnes VL, Abboud HE, Barnes JL. Mouse metanephric mesenchymal cell-derived angioblasts undergo vasculogenesis in three-dimensional culture. Am J Pathol 188: 168-184, 2018. (CMMM-1 and CMUB-1: Mouse Kidney Primordial Cells). Probetex, Inc. and UT Health San Antonio, San Antonio, TX. Link
Hauser PV1, Nishikawa M, Kimura H, Fujii T, Yanagawa N: Controlled tubulogenesis from dispersed ureteric bud-derived cells using a micropatterned gel. J Tissue Eng Regen Med. 762-771, 2014 Jan 29. doi: 10.1002/term.1871. Link (see Cover Photo)
Renal Regeneration Laboratory, Greater Los Angeles Veterans Affairs Healthcare System at Sepulveda, California USA
Velagapudi C, Nilsson R-P, Barnes VL, Arar M, Abboud HE, Barnes JL. Reciprocal induction of simple organogenesis by mouse kidney progenitor cells in three-dimensional co-culture. Am J Pathol 180:819-830, 2012. Link (Cover Photo, February Issue). (CMMM-1 and CMUB-1: Mouse Kidney Primordial Cells). Probetex and UT Health San Antonio, San Antonio, TX.
Nishikawa M, Yanagawa N, Kojima N, Yuri S, Hauser PV, Jo OD, Yanagawa N. Stepwise renal lineage differentiation of mouse embryonic stem cells tracing in vivo development. Biochem Biophys Res Comm 417:897-902, 2012. Renal Regeneration Laboratory, Greater Los Angeles Veterans Affairs Healthcare System at Sepulveda, California USA. Link
SERVICES
Contract Research:
Sun H, Olsen HS, Merigeon EY, So E, Burch E, Kinsey S, Papadimitriou JC, Drachenberg CB, Bentzen SM, Block DS, Strome SE, Zhang X: Recombinant human IgG1 based Fc multimers, with limited FcR bindng capacity, can effectively inhibit complement-mediated disease. J Autoimmun xx: 1-12, 2017. (rats) University of Maryland School of Medicine, Gliknik, Inc., Chengdu Military General Hospital China. Link
Riser BL, Najmabadi F, Garchow K, Barnes JL, Peterson DR, Sukowski EJ: Treatment with matricellular protein CCN3 blocks and/or reverses fibrosis development in obesity with diabetic nephropathy. Am J Pathol 184:2908–2921, 2014. (Rosalind Franklin University of Medicine and Science. Baxter Healthcare). Link
Rufanova VA, Alexanian A, Ostendorf T, Bokenmeyer D, Prosser S, Miller B, Sorokin A: Endothelin signaling via guanine exchange factor C3G in renal glomerular mesangial cells. Can J Physiol Pharmacol 88:808-816, 2010. (Medical College of Wisconsin). Link
McIntosh LM, Barnes JL, Barnes VL, McDonald JR. Selective CCR2-targeted macrophage depletion ameliorates experimental mesangioproliferative glomerulonephritis. Clin Exp Immunol 155:295-303, 2009. (Osprey Pharmaceuticals). Link
Histopathological Assessment of Organ Injury:
Kidney:
Devalaraja-Narashimha K, Meagher K, Luo Y, Huang C, Kaplan T, Muthuswamy A, Halasz G, Casanova S, O'Brien J, Peyser Boiarsky R, McWhirter J, Gartner H, Bai Y, MacDonnell S, Liu C, Hu Y, Latuszek A, Wei Y, Prasad S, Huang T, Yancopoulos G, Murphy A, Olson W, Zambrowicz B, Macdonald L, Morton LG. Humanized C3 Mouse: A Novel Accelerated model of C3 glomerulopathy. J Am Soc Nephrol. 32:99-114, 2021. PMID: 33288630; PMCID: PMC7894673. Histopathology
Bulley S, Fernández-Peña C, Hasan R, Leo MD, Muralidharan P, Mackay CE, Evanson KW, Moreira-Junior L, Mata-Daboin A, Burris SK, Wang Q, Kuruvilla KP, Jaggar JH. Arterial smooth muscle cell PKD2 (TRPP1) channels regulate systemic blood pressure. Elife. Dec 4;7. pii: e42628. 2018. (Mice). University of Tennessee Health Science Center , Memphis , TN.
Soni H, Kaminski D, Gangaraju R, Adebiyi A: Cisplatin-induced oxidative stress stimulates renal Fas ligand shedding. Ren Fail. 40:314-322, 2018. (Mice). University of Tennessee Health Science Center , Memphis , TN , USA.
Riser BL, Najmabadi F, Garchow K, Barnes JL, Peterson DR, Sukowski EJ: Treatment with matricellular protein CCN3 blocks and/or reverses fibrosis development in obesity with diabetic nephropathy. Am J Pathol 184:2908–2921, 2014. (Rosalind Franklin University of Medicine and Science)
McIntosh LM, Barnes JL, Barnes VL, McDonald JR. Selective CCR2-targeted macrophage depletion ameliorates experimental mesangioproliferative glomerulonephritis. Clin Exp Immunol 155:295-303, 2009. (Osprey Pharmaceuticals)
Liver:
Gardner JL, Turner SM, Bautista A, Lindwall G, Awada M, Hellerstein MK. Measurement of liver collagen synthesis by heavy water labeling: effects of profibrotic toxicants and antifibrotic interventions. Am J Physiol Gastrointestinal Liver Physiol 292:G1695-G1705, 2007. (KineMed, Inc.)