Kidney Progenitor Cells in Culture
Mouse and Rat Metanephric Mesenchymal Cells
Mouse and Rat Ureteric Bud Cells
Mouse and Rat Ureteric Bud Cells
- CMUB-1: Mouse Ureteric Bud Cells
- CRUB-1: Rat Ureteric Bud Cells
Mouse Metanephric Mesenchymal and Ureteric Bud Cells in Three-Dimension
CMMM-1 + CMUB-1 kit:
Kidney progenitor cells in 3-D matrigel implants in SCID mice provide a modern way to explore reciprocal cell-cell interactions between two kidney primordial progenitor cells types. UB cells develop into polarized tubuloids expressing collecting duct markers. MM cells develop into primitive capillary structures surrounding the periphery of tubuloids (Publication in Am J Pathol)
Probetex is developing new 3-D cell culture formats to optimize in vitro models of nephrogenesis.
Kidney progenitor cells in 3-D matrigel implants in SCID mice provide a modern way to explore reciprocal cell-cell interactions between two kidney primordial progenitor cells types. UB cells develop into polarized tubuloids expressing collecting duct markers. MM cells develop into primitive capillary structures surrounding the periphery of tubuloids (Publication in Am J Pathol)
Probetex is developing new 3-D cell culture formats to optimize in vitro models of nephrogenesis.
Regenerative Medicine- Cell-Based Therapeutics
Acute Kidney Injury Repair
Because our kidney progenitor cell lines retain differentiation potential, they have enormous potential in state-of-the art areas of research including cell-based therapy, stem cell biology, tissue engineering, and other burgeoning fields in regenerative medicine. With support from a Small Business Innovative Research Award granted by NIH/NIGMS, we are currently exploring the efficacy of our progenitor cell lines to accelerate repair and recovery during acute kidney injury. Probetex in cooperation with the University of Texas Health Science Center is testing the therapeutic potential of kidney embryonic progenitor cells to repair specific tubular and vascular structures via paracrine mechanisms and/or by cell integration in three established models of experimental acute kidney. (Grant summary).
Because our kidney progenitor cell lines retain differentiation potential, they have enormous potential in state-of-the art areas of research including cell-based therapy, stem cell biology, tissue engineering, and other burgeoning fields in regenerative medicine. With support from a Small Business Innovative Research Award granted by NIH/NIGMS, we are currently exploring the efficacy of our progenitor cell lines to accelerate repair and recovery during acute kidney injury. Probetex in cooperation with the University of Texas Health Science Center is testing the therapeutic potential of kidney embryonic progenitor cells to repair specific tubular and vascular structures via paracrine mechanisms and/or by cell integration in three established models of experimental acute kidney. (Grant summary).